Patentes

  • (Procedimiento para la Estimación de la Concentración de Fosfatos en Células Vivas, Colorante Xanténico y Síntesis del Mismo)
    • Alvarez-Pez, Jose María / Crovetto-Gonzalez, Luis / Cuerva-Carvajal, Juan Manuel / Giron-Gonzalez, Maria Dolores / Justicia-Ladron De Guevara, Jose / Orte, Angel / Ruedas-Rama, Maria Jose / Salto-Gonzalez, Rafael / Talavera-Rodriguez, Eva Maria / MARTÍNEZ-PERAGÓN, ÁNGELA / Paredes-Martínez, José Manuel
    • Fecha patente: 21/11/2024
    • Fecha solicitud: 10/05/2013
    • Fecha concesión: 21/11/2024
    • Ámbito: Europea
  • (Drug Delivery and Transfection Agents Based on Alkylsulfonate Functionalized Pamam Dendrimers)
    • Santoyo-Gonzalez, Francisco / Megía-Fernández, Alicia / Morales-Sanfrutos, Julia Isabel / Hernandez-Mateo, Fernando / Salto-Gonzalez, Rafael / Giron-Gonzalez, Maria Dolores
    • Fecha patente: 21/11/2024
    • Fecha solicitud: 14/07/2011
    • Fecha concesión: 19/04/2012
    • Resumen: The present invention describes vinyl sulfone-derived compds. that comprise a core of PAMAM derivatized with alkyl sulfonyl groups, and the method for prodn. thereof. These compds. form complexes with DNA fragments that are useful for cell transfection, and therefore the present invention likewise describes the use of these compds. as transfection agents. The agents are based on alkylsulfonate-functionalized PAMAM dendrimers, preferably PAMAM-G2 with alkyl, alkoxy, alkenyl substituents and sterol and derivs.; the agents are prepd. by Michael addn. reaction and functionalized with bioactive groups, e.g., rhodamine, DNA fragments, etc., for use in pharmaceutical compns. and in gene transfection. The sterol is selected from cholesterol, epicholesterol, lanosterol, ergosterol, and coprostenol.
    • Ámbito: Nacional
  • (Ciclooligosacáridos Anfifílicos Policatiónicos y su Uso Como Transportadores Moleculares.)
    • Gomez-Garcia, Marta / Giron-Gonzalez, Maria Dolores / Salto-Gonzalez, Rafael / Ortiz-Mellet, Carmen / Méndez-Ardoy, Alejandro / Sevillano-Tripero, Natalia / García-Fernández, José Manuel / Santoyo-Gonzalez, Francisco
    • Fecha patente: 14/09/2011
    • Fecha solicitud: 14/10/2010
    • Fecha concesión: 01/09/2011
    • Ámbito: Tratado de cooperación de patentes
  • (Triazolyl Containing Vinyl Sulfones As Double-Labeling Agents and Their Preparation and Use in the Marking of Biomolecules)
    • Lopez-Jaramillo, Francisco Javier / Morales-Sanfrutos, Julia Isabel / Hernandez-Mateo, Fernando / Salto-Gonzalez, Rafael / Giron-Gonzalez, Maria Dolores / Santoyo-Gonzalez, Francisco
    • Fecha patente: 03/09/2009
    • Fecha solicitud: 29/02/2008
    • Fecha concesión: 21/11/2024
    • Resumen: T_RESUMEN: THE INVENTION RELATES TO LABELING AGENTS CONTG. A COMPD. WITH TWO LABELED MOLS. AND A VINYL SULFONE GROUP OF FORMULA I. THE INVENTION ALSO RELATES TO THE COMPDS. OF FORMULA I, THE METHOD FOR OBTAINING SAME AND THE USES THEREOF IN THE MARKING OF BIOMOLS. AND, MORE SPECIFICALLY, PROTEINS. COMPDS. OF FORMULA I WHEREIN L AND L1 ARE INDEPENDENTLY LABELING MOLS.; X IS (CH2)1-20; Y IS ABSENT, (UN)SUBSTITUTED SO2-C1-10 ALKYLSULFONYL, SO2-C1-10 ALKYLARYLC1-10 ALKYL, AND SO2-(CH2CH2O)2-20CH2CH2; Z (UN)SUBSTITUTED C1-10 ALKYLSULFONYL, C1-10 ALKYLARYLC1-10 ALKYL, AND (CH2CH2O)2-20CH2CH2; ARE CLAIMED. EXAMPLE COMPD. II WAS PREPD. BY A MULTISTEP PROCEDURE (PROCEDURE GIVEN). ALL THE INVENTION COMPDS. WERE EVALUATED FOR THEIR LABELING ABILITY OF PROTEINS.
    • Ámbito: Tratado de cooperación de patentes
  • (Methods of Production of Porous Biotin Carriers and Uses Thereof)
    • Santoyo-Gonzalez, Francisco / Giron-Gonzalez, Maria Dolores / Ortega-Muñoz, Mariano / Hernandez-Mateo, Fernando / Salto-Gonzalez, Rafael / Sevillano-Tripero, Natalia
    • Fecha patente: 08/01/2009
    • Fecha solicitud: 02/07/2007
    • Fecha concesión: 21/11/2024
    • Resumen: T_RESUMEN: THE INVENTION RELATES TO A COMPD. I [X = S, SO2, DOESN'T EXIST; Y = O, NH; Z = CH2 OR ME, WHEN X DOESN'T EXIST; R1 = O, NH; R2 = C1-10-ALKYL, (CH2CH2O)MCH2, (CH2)4CH(NH2)CO2CH2; M = 0 - 10; B = B1, B2; C = POROUS SUPPORT; R3 = C1-10-ALKYL, (CH2CH2O)MCH2, (CH2)4CH(NH2)CO2CH2; R4 = O, C(:O)R1, R1C(:O)R1, R1C(:S)R1; N = 1 - 11] COMPRISING BIOTIN JOINED TO A POROUS CARRIER BY MEANS OF A LINKER CONTG. THE 1,2,3-TRIAZOLE GROUP. THE PROCEDURE FOR THE PREPN. OF I COMPRISES: (A) FUNCTIONALIZATION OF THE POROUS SUPPORT SO THAT IT CONTAINS A TERMINAL AZIDE OR ALKYNE GROUP; (B) FUNCTIONALIZATION OF BIOTIN OR DERIV. SO THAT IT CONTAINS A TERMINAL AZIDE OR ALKYNE GROUP; AND (C) REACTION OF THE DERIVATIZED POROUS SUPPORT WITH THE FUNCTIONALIZED BIOTIN VIA 1,3-DIPOLAR CYCLOADDN. REACTION, I.E., CLICK CHEM. THUS, BIOTIN LINKED IMIDAZOLE DERIV. II [C' = SILICA GEL] WAS PREPD. FROM BIOTIN VIA CHLORINATION WITH SOCL2, AMIDATION WITH PROPARGYLAMINE IN CH2CL2, AND 1,3-DIPOLAR CYCLOADDN. (CLICK CHEM.) WITH SILICA GEL 3-AZIDOPROPYL ETHER. THE MODIFIED SILICA GEL WAS PREPD. FROM (3-CHLOROPROPYL)TRIETHOXYSILANE VIA AZIDATION WITH NAN3 IN 2-BUTANONE CONTG. BU4NI FOLLOWED BY HEATING WITH SILICA GEL IN PHME. THE INVENTION ALSO RELATES TO THE METHOD FOR OBTAINING SAID COMPD. AND TO THE USES THEREOF FOR PURIFYING AVIDIN AND BIOTINYLATED PROTEINS, AND FOR THE FLUORESCENT MARKING OF AVIDIN.
    • Ámbito: Otros
  • (Hiv-Protease-Binding Compounds and Methods of Use)
    • Furth-,Paul S. / Caldera-,Patricia S. / Alvarez-,Juan C. / Salto-Gonzalez, Rafael / Decamp-,Dianne L. / Babé-,Lilia M. / Sui-,Zhihua / De Voss-,James J. / Ortiz De Montellano-,Paul R. / Craik-,Charles S. / Kuntz-,Irwin D.
    • Fecha patente: 21/11/2024
    • Fecha solicitud: 10/12/1996
    • Fecha concesión: 10/12/1996
    • Observación: US PATENT NO 5,583,000
    • Ámbito: Otros